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. 2021 Jul 23;57(8):743. doi: 10.3390/medicina57080743

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Outcome measurements between real and sham continuous theta-burst stimulation groups before brain stimulation, after brain stimulation on the 5th day, and at follow-up 1–3 months later. (A) The degree of annoyance of ear fullness, (B) duration of tinnitus, (C) visual analog scale (VAS) of tinnitus annoyance, (D) Tinnitus Handicap Inventory (THI), functional subscale, (E) THI, emotional subscale, (F) THI, catastrophic subscale, (G) THI, total score, (H) pitch, (I) loudness, (J) minimal masking level, and (K) residual inhibition. A generalized linear mixed model approach showed significant differences of changing pattern in VAS and MML over the three visits between two groups ((C), p = 0.002 and (K), p = 0.033, respectively). This was supposed to be due to the large changes over time in the sham group, but there were no significant differences in the mean values of VAS and MML in paired analyses in each group (all ps > 0.2). Besides, there were no significant differences in the mean values of VAS and MML between the two groups at each visit (ps > 0.2 and ps > 0.1, respectively).