Table 4.

Factors of dementia among different models using Cox regression and the Fine–Gray competing risk model

Antibiotics	Toxoplasmosis subgroup	Events	PYs	Rate (per 105 PYs)	Competing risk in the model
					Adjusted HR	95% CI	95% CI	P-value*
Sulfadiazine	With toxoplasmosis, without sulfadiazine	5	1015.10	492.56	Reference
	With toxoplasmosis, with sulfadiazine	16	3571.66	447.97	0.909	0.887	0.932	0.013
	With toxoplasmosis, with sulfadiazine < 30 days	5	1047.15	477.48	0.967	0.943	0.991	0.046
	With toxoplasmosis, with sulfadiazine 30–364 days	5	1257.18	397.72	0.808	0.782	0.845	< 0.001
	With toxoplasmosis, with sulfadiazine ≥ 365 days	6	1267.33	473.44	0.932	0.901	0.986	0.041
Clindamycin	With toxoplasmosis, without clindamycin	5	879.28	568.65	Reference
	With toxoplasmosis, with clindamycin	16	3707.48	431.56	0.759	0.732	0.797	< 0.001
	With toxoplasmosis, with clindamycin < 30 days	5	1048.48	476.88	0.832	0.784	0.863	< 0.001
	With toxoplasmosis, with clindamycin 30–364 days	5	1056.84	473.11	0.821	0.776	0.859	< 0.001
	With toxoplasmosis, with clindamycin ≥ 365 days	6	1602.17	374.49	0.664	0.602	0.692	< 0.001
Sulfadiazine	With toxoplasmosis, without antibiotics	1	198.15	504.67	Reference
and / or	With toxoplasmosis, with any antibiotics	20	4388.61	455.72	0.927	0.894	0.950	0.022
Clindamycin	With toxoplasmosis, with any antibiotics < 30 days	5	1030.45	485.22	0.970	0.942	0.995	0.047
	With toxoplasmosis, with any antibiotics 30–364 days	7	1544.20	453.31	0.965	0.931	0.983	0.041
	With toxoplasmosis, with any antibiotics ≥ 365 days	8	1813.96	441.02	0.864	0.803	0.899	< 0.001
	With toxoplasmosis, with both antibiotics	12	2890.53	415.15	0.812	0.694	0.872	< 0.001
	With toxoplasmosis, with both antibiotics < 30 days	5	1065.18	469.40	0.853	0.793	0.901	< 0.001
	With toxoplasmosis, with both antibiotics 30–364 days	3	769.82	389.70	0.750	0.615	0.830	< 0.001
	With toxoplasmosis, with both antibiotics ≥ 365 days	4	1055.54	378.95	0.721	0.594	0.825	< 0.001

*Chi-square/Fisher exact test for categorical variables and t-test for continuous variables, PYs person-years, Adjusted HR adjusted hazard ratio (adjusted for the variables listed in Table 1), CI confidence interval