Fig. 1.

Genealogical tree of an informative family in which DES had been administered to the mother (I-2) for 3 months after the birth of each of her 11 children (4 boys + 7 girls) (II-1 to -11) to stop lactation, between 1956 and 1971. The first child (II-1) was thus not exposed to DES, since the mother started DES treatment after her birth. Six of the daughters (II-4, II-6, II-7, II-8, II-9, II-10) suffered from endometriosis (gray), whereas the oldest daughter (II-1, not exposed) and her descendants did not present this disease. The 11 children gave birth to 26 grandchildren (13 boys and 13 girls) (III-1 to -27), of which III-10, III-16, III-18, III-20, III-24 and III-25 have endometriosis. The fourth generation (IV-1 to -11) is beginning, and IV-5 is the only one to have attained menarche, with severe, chronic drug-resistant dysmenorrhea, possibly hiding endometriosis (gray point). We also note that III-11 and III-13 presented hypospadias