Table 5.

Per-residue free energy for complexes formed between alfuzosin, prazosin, terazosin, and vardenafil with EGFR (values kcal/mol).

Residue	EGFRalfuzosin	EGFRprazosin	EGFRterazosin	EGFRvardenafil
L718	−2.2	−1.2	−2.2	−2.4
G719				−0.9
G721				−1.2
F723				−0.6
T725				−0.7
V726	−1.9	−2.0	−2.1	−3.0
A743	−1.0	−0.9	−1.0	−0.7
I744			−0.7
K745	−1.4	−1.2	−2.0	−3.2
M766			−0.6
L777		−1.9	−1.1
L788	−1.0	−1.1	−1.6
I789	−1.3		−0.5
T790	−0.5	−1.2	−1.1
L792		−0.9	−0.8	−0.9
M793	−1.0	−1.1	−0.7	−0.5
G796	−1.0	−0.5	−1.0	−0.7
C797	−1.0	−0.4	−0.9	−1.3
R841				−2.0
L844	−2.0	−2.2	−2.2	−0.8
T854	−1.3	−1.7	−1.7
F856	−1.0	−0.6	−0.5
L858	−0.6			−0.6