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The mechanism of action of salinomycin: (1) Interfering with ABC transporters; (2) Accumulation and sequestration of iron in lysosomes; (3) Interfering with the Wnt/β-catenin, Hedgehog, Notch, and Akt signaling pathways; (4) and (5) Interfering with ion pumps; (6) Induction of reactive oxygen species (ROS) (Figure created with BioRender.com [accessed on 25 June 2021]).
