Table 2.
Change in serum urate level (mg/dL) and body mass index (kg/m2) in SPIRIT compared to baseline at 3 months, 6 months, and 12 months, by randomized arm and among all participants.
| 3-Months | 6-Months | 12-Months | |||||
|---|---|---|---|---|---|---|---|
| Assignment | Baseline Mean (SD) | Difference (95% CI) | p | Difference (95% CI) | p | Difference (95% CI) | p |
| Serum urate, mg/dL | |||||||
| Self-Directed | 5.8 (1.3) | −0.07 (−0.28, 0.14) | 0.52 | −0.12 (−0.33, 0.08) | 0.23 | −0.25 (−0.48, −0.01) | 0.04 |
| Coach-Directed | 5.8 (1.1) | 0.26 (0.04, 0.47) | 0.02 | 0.17 (−0.08, 0.42) | 0.18 | 0.00 (−0.26, 0.26) | 0.99 |
| Metformin | 5.3 (1.4) | 0.16 (−0.04, 0.36) | 0.12 | 0.16 (−0.07, 0.39) | 0.16 | 0.07 (−0.17, 0.30) | 0.58 |
| All participants | 5.6 (1.3) | 0.11 (−0.01, 0.24) | 0.08 | 0.07 (−0.07, 0.20) | 0.32 | −0.06 (−0.21, 0.08) | 0.39 |
| Body mass index, kg/m2 | |||||||
| Self-Directed | 34.7 (4.9) | −0.24 (−0.47, −0.00) | 0.048 | −0.27 (−0.60, 0.05) | 0.10 | −0.14 (−0.59, 0.30) | 0.53 |
| Coach-Directed | 35.3 (4.9) | −1.09 (−1.46, −0.73) | <0.001 | −1.31 (−1.84, −0.77) | <0.001 | −1.02 (−1.60, −0.45) | <0.001 |
| Metformin | 34.9 (6.3) | −0.49 (−0.80, −0.17) | 0.002 | −0.82 (−1.26, −0.38) | <0.001 | −1.14 (−1.76, −0.52) | <0.001 |
| All participants | 34.9 (5.4) | −0.59 (−0.78, −0.41) | <0.001 | −0.79 (−1.06, −0.53) | <0.001 | −0.75 (−1.08, −0.43) | <0.001 |
| eGFR (CKD-EPI), mL/min/1.73 m2 | |||||||
| Self-Directed | 84.2 (17.2) | 4.24 (0.58, 7.89) | 0.02 | 2.78 (−0.66, 6.22) | 0.11 | 4.37 (0.67, 8.07) | 0.02 |
| Coach-Directed | 83.6 (20.1) | 0.23 (−2.73, 3.20) | 0.88 | 1.38 (−1.97, 4.73) | 0.42 | 0.94 (−2.56, 4.44) | 0.60 |
| Metformin | 86.8 (19.1) | 1.40 (−0.56, 3.36) | 0.16 | 3.28 (0.02, 6.54) | 0.048 | −0.00 (−3.32, 3.32) | 1.00 |
| All participants | 84.9 (18.8) | 1.99 (0.27, 3.71) | 0.02 | 2.50 (0.56, 4.43) | 0.01 | 1.81 (−0.25, 3.87) | 0.09 |
Note that these estimates were generated with generalized estimating equation models and as a result differ slightly from the Figure.