Table 4.
Examples of 3D-bioprinted cancer cell models.
| Model | Tumour Type (Cell line) | Matrix | Drug | Type of Printer | Features | References |
|---|---|---|---|---|---|---|
| Glioma-vascular niche | Brain cancer (Glioblastoma multiforme) | Collagen type with laminin | N/A | N/A | Angiogenesis, Cell–cell/Cell–ECM interaction | [81] |
| In vitro Cell Laden | Cervical cancer (cell line HeLa) | Gelatine, alginate, fibrinogen | Paclitaxel | N/A | Drug toxicity study | [84] |
| 3D bone matrix | Breast cancer (cell line MDA-MB-231, MCF-7, MSC) | PEG PEG-DA HA |
N/A | Stereolithography | Metastatic study | [19] |
| 3D Microfluidic device | MCF-7 breast cancer, SW480 colon cancer, (cell line PC3) prostate cancer | N/A | Anti-EpCAM antibodies | Multi-jet printing | CTC isolation | [98] |
| 3D Drug screening | Hepatocyte/ADSC | Gelatine, alginate, fibrinogen | 5-FU, AP, matrine | N/A | Drug screening | [102] |
Abbreviations: 5-FU: 5-fluorouracil, ADSC: adipose-derived stem cells, AP: astragalus polysaccharide, CTC: circulating tumour cells, ECM: extracellular matrix, EpCAM: epithelial cell adhesion molecule, HA: hydroxyapatite, MSC: mesenchymal stem cell, PEG: polyethylene glycol, PEG-DA: polyethylene glycol diacrylate.