Table 2.
Levetiracetam concentration and medication data.
| Characteristics | 519 Patients 672 Samples |
|---|---|
| Sample Data | n = 672 |
| LEV dose, median (mg/day) | 1500 |
| LEV dose, range (Q25%–Q75%) (mg/day) | 20–5000 (1000–2000) |
| LEV dose per body weight, median (mg/kg/day) | 25.5 |
| Range of LEV dose per body weight (Q25%–Q75%) | 3.03–133.0 (14.9–38.8) |
| LEV serum concentration, median (mg/L) | 17.3 |
| Range of LEV serum concentration (Q25%-Q75%) | 0.8–95.0 (8.5–28.3) |
| Sub-therapeutic level (<10 mg/L), n (%) | 201 (29.9) |
| Therapeutic level (10–40 mg/L), n (%) | 393 (58.5) |
| Supra-therapeutic level (>40 mg/L), n (%) | 78 (11.6) |
| Patient data | n = 519 |
| Number of co-prescribed drugs 1, n (%) | |
| Mean (median) | 2.08 (2) |
| Range (Q25%–Q75%) | 0–8 (1–3) |
| None | 101 (19.5) |
| One | 137 (26.4) |
| Two | 99 (19.1) |
| Three | 77 (14.8) |
| Four | 49 (9.4) |
| Five or more | 56 (10.8) |
1 Neurologic/psychiatric drugs, including antiepileptic drugs. Abbreviations: LEV, levetiracetam; Q25%, 25th percentile; Q75%, 75th percentile; PO, oral; IV, intravenous.