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(a) Preparation of Fe3O4 NPs by chemical co-precipitation and (b) oxidation into γ-Fe2O3 particles; (c) surface modification of γ-Fe2O3 NPs with oleic acid; (d) formulation of CDDP-loaded γ-Fe2O3/PLGA (core/shell) particles by nanoprecipitation solvent evaporation; and (e) preparation of CDDP-loaded (γ-Fe2O3/PLGA)/CS (core/shell)/shell NPs by coacervation.
