Table 2.
Comparison of significant changes in the fetal and placental weights, MVM and BM system A/L amino acid transport activity and isoform expression, maternal, fetal amino acid concentration, and in vivo transplacental amnio acid transport activity in MNR baboons as compared to control at different gestation ages.
| Parameters | Gestation Day 120 | Gestation Day 140 | Gestation Day 165 |
|---|---|---|---|
| Reference | [34] | Current study | [11,38] |
| Fetal weight | ⬌ | ⬌ | ↓ |
| Placental weight | ⬌ | ⬌ | ↓ |
| MVM System A activity | ↓ | ↓ | ↓ |
| MVM System A amino acid transporter isoforms (SNAT1,2 and 4) expression | ⬌ | ↓SNAT2 | ↓SNAT2; ⬌ SNAT1, SNAT4 |
| MVM System L activity | ⬌ | ↓ | ↓ |
| MVM System L amino acid transporter isoforms expression (LAT1 and 2) | ⬌ | ↓LAT1 | ↓LAT1 and LAT2 |
| MVM Taurine transporter expression | ⬌ | ⬌ | ↓ |
| BM System L activity | ⬌ | ↓ | ↓ |
| BM System L amino acid transporter LAT1 isoform expression | ⬌ | Not studied | Not studied |
| Maternal plasma concentration of amino acids | ⬌ | Not studied | ↓Aspartic acid, glutamic acid, tyrosine, tryptophan, phenylalanine, leucine, and ornithine; ↑Glycine |
| Fetal plasma concentration of amino acids | ↓ Leucine and isoleucine. ↑Citrulline |
Not studied | ↓Taurine, tyrosine, phenylalanine, leucine, and ornithine |
| In vivo transplacental amino acid transport | Not studied | ↓Tryptophan | ↓Leucine, isoleucine, methionine, phenylalanine, threonine, and tryptophan |