Figure 4.

Effect of PALO and/or MLA on (a) PI and (b) DI during NOR test and (c) time spent in the target quadrant during MWM test in HFFD/LPS-induced AD model. Values are shown in scatter plots and expressed as mean ± SD (n = 11/group). Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test; (t) denotes significance using unpaired Student’s t-test between 2 groups; p < 0.05. The symbols (□) and (○) indicate additive and synergistic interactions, respectively, using coefficient drug index (CDI). PALO (0.1 mg·kg⁻¹; i.p) and/or MLA (5.6 mg·kg⁻¹; i.p) were administered 3 h after LPS injection and for 8 days. Training for MWM (day 4–7) was followed by probe test (on day 8). The NOR test habituation and familiarization phases (days 6 and 7) were followed by the probe test (day 8). MWM: Morris water maze.