Figure 9.

Effects of PALO and/or MLA on CA1 hippocampal histopathological examination of amyloid plaques in HFFD/LPS-induced AD model. Photomicrograph of Congo red stained sections from CA1 region of hippocampus of rats in (a) NFD shows the normal histology of neuronal cells with no deposition of amyloid β plaques (AβP). Section of (b) AD model shows multiple intracellular and extracellular deposition of AβP; meanwhile, sections of the (c) PALO treated group shows mild deposition of these plaques. Sections of the (d) MLA treated group shows multifocal moderate intracellular deposition of AβP, the section of (e) PALO + MLA shows no deposition of AβP (Scale bar 20μm, ×600). Panel (f) represents the number of congophilic AβP counted in 5 random non-overlapping microscopic field (×600) in each section. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test; p < 0.05. PALO (0.1 mg·kg⁻¹; i.p) and/or MLA (5.6 mg·kg⁻¹; i.p) were administered 3 h after LPS injection and for 8 days.