Table 4.
Pharmacokinetic parameters of inotodiol after intravenous bolus administration and oral bolus administration (n = 3 for each group).
| Parameters | 1 Intravenous | 1 Oral |
|---|---|---|
| λz (1/min) | 0.016 ± 0.01 | 0.005 ± 0.00 |
| T1/2 (min) | 49.35 ± 14.1 | 138.6 ± 30.3 |
| Tmax (min) | 40 ± 14.1 | |
| Cmax (ng/mL) | 2582 ± 74.2 | 49.56 ± 14.2 |
| Cl (ng/min) | 0.004 ± 0.00 | |
| AUC0–t (ng×min/mL) | 109500 ± 5670 | 6176 ± 455 |
| MRT0–t (min) | 32.30 ± 0.55 | 103.7 ± 3.54 |
| Vd (mL) | 0.281 ± 0.08 | |
| F (%) | 0.45 ± 0.0 |
1 data was represented as mean ± standard deviation.