Table 1.

Summary of corona- and core-forming blocks, reaction solvents, obtained morphologies, and applications of protein–polymer hybrid nanostructures prepared via PISA.

Corona-Forming Block	Core-Forming Block	PISA Solvent	Morphologies 1	Application	Ref.
BSA, HSA, reduced human calcitonin	PS	PBS (w. DMSO in some cases)	S	Nanoreactors	[54]
BSA, HSA, GOx, β-galactosidase	PS, PDMAEMA, substituted styrenes	PBS, water	S	Nanoreactors	[55]
BSA	MA, MMA, tBA, tBMA	Water	S	-	[56]
BSA	PHPMA	Water	S	Drug delivery	[57]
HSA	PHPMA	PBS	S/W/V	Protein delivery	[58]
HSA	PDPA	PBS	S/W/A/V	Bioimaging	[46]
IFN-g-POEGMA	PHPMA	PBS	S	Antitumor agents	[47]
sfGFP	PHPMA	PBS	S	-	[59]
GOx/HRP	PHPMA	PBS	S	Glucose detection	[60]
CALB	NIPAAm, tBAm, MA	Water/methanol	S	-	[61]

¹ Key: S—spherical micelles, W—worm-like micelles, V—vesicles, A—aggregates.