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. 2021 Aug 18;11(8):803. doi: 10.3390/jpm11080803

Table 2.

Thicknesses in the 9 layers of the retina and in the 9 ETDRS regions. Mean ± SD (μm) (normal distribution, Shapiro–Wilk test p ≥ 0.05). Median [interquartile range] (μm) (non-normal distribution, Shapiro–Wilk test p < 0.05).

Layer RNFL GCL IPL INL OPL ONL RPE IRL ORL
C BD C BD C BD C BD C BD C BD C BD C BD C BD
Central 12.0
[3.0]
11.65 ± 2.09 16.62 ± 3.78 14.0
[5.5]
21.26 ± 3.51 20.12 ± 4.86 20.76 ± 6.26 18.0
[10.0]
25.71 ± 5.60 23.0
[8.5]
95.0
[16.25]
92.0
[15.0]
16.0
[2.0]
15.0
[2.0]
189.45 ± 25.03 185.06 ± 20.48 90.0
[5.0]
88.18 ± 4.59
p (U-test) = 0.14
AUC = 0.62
p (U-test) = 0.17
AUC = 0.61
p (t-test) = 0.32
AUC = 0.61
p (U-test) = 0.86
AUC = 0.51
p (U-test) = 0.47
AUC = 0.56
p (U-test) = 0.46
AUC = 0.56
p (U-test) = 0.056
AUC = 0.66
p (t-test) = 0.52
AUC = 0.58
p (U-test) = 0.28
AUC = 0.59
Inner Nasal (IN) 22.21 ± 2.88 20.47 ± 3.78 53.0
[6.25]
44.71 ± 6.94 43.0
[4.25]
38.59 ± 4.12 40.50
[5.0]
43.47 ± 3.73 32.0
[7.0]
35.47 ± 8.46 76.0
[16.25]
70.94 ± 16.15 15.05 ± 1.62 15.0
[3.5]
267.0
[25.0]
254.06 ± 15.31 82.50 ± 3.09 81.82 ± 3.09
p (t-test) = 0.06
AUC = 0.68
p (U-test) = 0.00
AUC = 0.82
p (U-test) = 0.00
AUC = 0.83
p (U-test) = 0.041
AUC = 0.67 #
p (U-test) = 0.56
AUC = 0.55 #
p (U-test) = 0.79
AUC = 0.52
p (U-test) = 0.71
AUC = 0.53 #
p (U-test) = 0.009
AUC = 0.72
p (t-test) = 0.45
AUC = 0.56
Outer Nasal (ON) 51.90 ± 7.99 44
[18]
38.00
[6.0]
36.82 ± 5.08 30.0
[3.25]
29.35 ± 3.46 34.0
[4.0]
37.12 ± 3.39 28.0
[4.25]
29.0
[4.0]
55.81 ± 7.98 55.18 ± 9.63 13.0
[2.0]
13.00 ± 1.77 239.0
[18.75]
239.29 ± 11.27 78.95 ± 2.84 77.71 ± 2.78
p (U-test) = 0.18
AUC = 0.61
p (U-test) = 0.62
AUC = 0.54
p (U-test) = 0.91
AUC = 0.51
p (U-test) = 0.001
AUC = 0.78 #
p (U-test) = 0.055
AUC = 0.66 #
p (t-test) = 0.79
AUC = 0.52
p (U-test) = 0.66
AUC = 0.54
p (U-test) = 0.87
AUC = 0.51 #
p (t-test) = 0.13
AUC = 0.62
Inner Superior (IS) 25.07 ± 2.62 24.0
[3.5]
52.0
[5.25]
51.00
[7.0]
42.0
[4.0]
40.06 ± 3.36 40.0
[4.5]
43.29 ± 2.69 31.0
[6.0]
30.0
[11.0]
73.50
[11.0]
69.94 ± 11.80 16.0
[3.0]
16.0
[3.0]
264.0
[23.75]
263.0
[17.5]
82.0
[3.5]
81.0
[3.5]
p (U-test) = 0.12
AUC = 0.63
p (U-test) = 0.021
AUC = 0.69
p (U-test) = 0.051
AUC = 0.66
p (U-test) = 0.009
AUC = 0.72 #
p (U-test) = 0.83
AUC = 0.52
p (U-test) = 0.65
AUC = 0.54
p (U-test) = 0.97
AUC = 0.50
p (U-test) = 0.46
AUC = 0.56
p (U-test) = 0.14
AUC = 0.62
Outer superior (OS) 39.57 ± 5.56 38.0
[.8.0]
36.0
[5.0]
33.88 ± 3.66 29.0
[3.25]
27.76 ± 2.61 31.83 ± 2.58 33.82 ± 2.83 25.0
[3.0]
26.0
[3.0]
61.45 ± 8.55 59.12 ± 6.70 14.0
[2.25]
13.06 ± 1.30 225.5
[15.25]
229.0
[19.0]
80.00 ± 2.78 78.00 ± 2.47
p (U-test) = 0.50
AUC = 0.56
p (U-test) = 0.16
AUC = 0.62
p (U-test) = 0.13
AUC = 0.63
p (t-test) = 0.012
AUC = −0.69 #
p (U-test) = 0.56
AUC = 0.55 #
p (t-test) = 0.32
AUC = 0.58
p (U-test) = 0.18
AUC = 0.61
p (U-test) = 0.70
AUC = 0.53
p (t-test) = 0.013
AUC = 0.70
Inner Temporal (IT) 17.0
[3.0]
17.06 ± 1.68 47.50
[6.5]
44.0
[11.0]
41.50
[4.25]
40.0
[7.5]
37.0
[5.0]
40.47 ± 4.53 29.5
[5.0]
31.0
[3.5]
73.50
[9.0]
71.35 ± 10.71 14.0
[3.0]
15.0
[3.0]
250.5
[21.0]
246.0
[18.5]
82.0
[4.25]
80.94 ± 3.34
p (U-test) = 0.36
AUC = 0.57
p (U-test) = 0.020
AUC = 0.69
p (U-test) = 0.18
AUC = 0.61
p (U-test) = 0.017
AUC= 0.70 #
p (U-test) = 0.28
AUC = 0.59 #
p (U-test) = 0.32
AUC = 0.58
p (U-test) = 0.82
AUC = 0.52
p (U-test) = 0.20
AUC = 0.61
p (U-test) = 0.24
AUC = 0.60
Outer Temporal (OT) 19.0
[2.0]
20.0
[3.5]
37.5
[7.0]
35.0
[6.5]
32.50
[3.0]
32.12 ± 3.59 33.50
[4.25]
34.94 ± 2.08 26.5
[2.25.]
28.65 ± 2.71 57.57 ± 7.36 54.94 ± 7.06 13.0
[1.0]
12.24 ± 1.09 208.0
[15.25]
207.0
[19.5]
78.40 ± 2.67 77.06 ± 2.05
p (U-test) = 0.43
AUC= 0.56 #
p (U-test) = 0.27
AUC = 0.59
p (U-test) = 0.57
AUC = 0.55
p (U-test) = 0.042
AUC = 0. 67 #
p (U-test) = 0.020
AUC = 0. 69 #
p (t-test) = 0.21
AUC = 0.60
p (U-test) = 0.27
AUC = 0.59
p (U-test) = 0.72
AUC = 0.53 #
p (t-test) = 0.067
AUC = 0.65
Inner Inferior (II) 26.62 ± 4.36 24.76 ± 4.24 53.0
[6.0]
50.0
[8.0]
41.0
[4.0]
39.0
[6.5]
41.0
[4.0]
45.47 ± 4.16 34.57 ± 8.54 37.47 ± 8.54 63.95 ± 11.69 61.12 ± 15.81 14.43 ± 1.65 14.29 ± 1.45 262.5
[19.5]
259.0
[18.5]
80.02 ± 2.78 79.41 ± 2.74
p (t-test) = 0.14
AUC = 0.64
p (U-test) = 0.014
AUC = 0.70
p (U-test) = 0.035
AUC = 0.67
p (U-test) = 0.001
AUC = 0 79 #
p (t-test) = 0.24
AUC = 0.59 #
p (t-test) = 0.51
AUC = 0.53
p (t-test) = 0.77
AUC = 0.52
p (U-test) = 0.20
AUC = 0.61
p (t-test) = 0.44
AUC = 0.56
Outer Inferior (OI) 41.07 ± 7.83 38.82 ± 9.19 31.50
[5.25]
32.0
[4.0]
26.0
[4.0]
26.35 ± 2.32 31.0
[3.0]
32.94 ± 2.11 27.0
[5.0]
27.59 ± 2.55 50.83 ± 6.98 49.35 ± 7.75 12.50
[1.25]
12.0
[2.0]
208.5
[18.5]
208.0
[15.5]
76.95 ± 2.95 76.41 ± 2.87
p (t-test) = 0.35
AUC = 0.62
p (U-test) = 0.84
AUC = 0.52 #
p (U-test) = 0.73
AUC = 0.53
p (U-test) = 0.004
AUC = 0.74 #
p (U-test) = 0.29
AUC = 0.58 #
p (t-test) = 0.48
AUC = 0.53
p (U-test) = 0.38
AUC = 0.57
p (U-test) = 0.79
AUC = 0.52
p (t-test) = 0.52
AUC = 0.54

Abbreviations: T-test: Student’s t test, U-test: Mann–Whitney U test, AUC: area under the receiver operation curve, #: the values in BD exceed the values of the controls. BD, bipolar disorder; C: controls; RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium; IRL, inner retinal layer; ORL, outer retinal layer.