Figure 1.

Virucidal activity of TY-1 against SARS-CoV-2. (a)–(f) SARS-CoV-2 solution ((a) ancestral strain, (b) Alpha strain, (c) Beta strain, (d) Gamma strain, (e) Delta strain, (f) Kappa strain) was mixed with TY-1 at several different concentrations. As a diluent control, dextrin (2.5 mg/mL) was mixed with the viral solution. The mixtures were incubated at 22–25 °C from 1 min to 24 h (a) or for 10 min (b)–(f); then, the viral titers were evaluated. The detection limits of the viral titer were 1.25 log₁₀ TCID₅₀/mL in the dextrin and TY-1 (0.3–1.3 mg/mL) groups and 2.25 log₁₀ TCID₅₀/mL in the TY-1 (2.5 and 5.0 mg/mL) groups. The results are indicated as mean ± SD (n = 4–12 per group). Student’s t-tests were performed to evaluate the statistical significance of the differences between the dextrin and each TY-1 groups; * p < 0.05; ** p < 0.01; *** p < 0.001; NT: not tested.