Figure 3.

Acetate, propionate, and butyrate levels (mM) in the distal colon reactors during the long-term pathogut^TM study (11 weeks) (test 2). Upon inoculation and stabilisation of the fecal inoculum of donor A during the two weeks preceding the study (−14–0 days), a control period (0–14 days) was followed by a clindamycin treatment period (CLI: 14-21 days) which resulted in C. difficile infection (CDI: 21–49 days). From then on, while the blank was treated with vancomycin (VNC: 49–54 days), the other two arms additionally received 2′FL and MIX, respectively. 2′FL and MIX were further administered during the washout period (WO: 54–77 days). While the absolute levels are presented for the blank reactor (A), the levels upon treatment with 2′FL (B) and MIX (C) are presented as the difference versus the blank reactor. 2′FL = 2′-O-fucosyllactose, LNnT = lacto-N-neotetraose, MIX = 4:1 mixture of 2′FL/LNnT.