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. 2021 Jul 31;12(8):914. doi: 10.3390/mi12080914

Table 6.

Conductive nanomaterials as delivery vehicles for cardiac gene therapy.

Nanomaterials Delivered Gene Outcomes
AuNPs [134] Deoxyribozyme (DNAzyme) Knockdown of 50% TNF-α expression. Improved anti-inflammatory pathways
AuNPs [135] Antago-miR155 Improved blood pumping ability
AuNPs [136] Circ-Amolt1 Cardio-protection against Doxorubicin-induced cardiomyopathy
SWCNTs [137] siRNA/Caspase3 Casepase3 silencing, 1.42-folds increase in the infarcted wall thickness with reduced scar size
Graphene [138] DNAVEGF Improved angiogenesis, better cardiac performance

Abbreviations: TNF: tumour necrosis factor, VEGF: vascular endothelial growth factor, DNA: deoxyribonucleic acid, AuNPs: gold nanoparticles, SWCNTs: single-wall carbon nanotubes.