Figure A2.

Cell viability of MIN6 pancreatic β cells determined by the resazurin assay tested at a concentration of 10 µg/mL. Stimulating plant extracts: 1889: Populus nigra, 1955: Quillaja saponaria, 2088: Anagallis arvensis, 2332: Allium sativum, 2903: Sapindus mukorossi, 2906: Sapindus mukorossi, 3137: Albizia julibrissin, 2936: Quillaja saponaria, 3318: Gleditsia sinensis and 3664: Lycium barbarum, (A). Suppressing plant extracts: 921: Calendula officinalis, 1050: Rosae, 1157: Vaccinium vitis-idaea, 1768: Cistus incanus, 1874: Vaccinium vitis-idaea, 1904: Myrtus communis, 2006: Actaea spicata L., 2332: Acacia catechu, 2359: Filipendula ulmaria and 2742: Terminalia arjuna (B). Active pharmaceutical ingredients: 250 µM DZ, 300 µM tolbutamide, 1 mM chlorpropamide, 1 µM glibenclamide, 20 µM glipizide, 10 µM glimepiride and 1 µM repaglinide (C). DMSO (D). Data are normalized to untreated cells (0 mM glucose or 0% DMSO = 100% viability) and presented as the mean ± SEM. n ≥ 8; **** p < 0.0001, *** p < 0.001, and * p < 0.05 indicate a significant difference compared to the untreated cells.