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. 2021 Aug 15;13(8):2792. doi: 10.3390/nu13082792

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LCs supplementation alleviates renal fibrosis, necrosis, and macrophage infiltration in cisplatin-induced nephrotoxicity rats. (A) Immunohistochemistry shows F4/80⁺ macrophage infiltration and quantitative analysis. (B) Immunohistochemistry shows cleaved caspase-3-positive cells and quantitative analysis of tubular necrosis. (C) Hydroxyproline levels. (D) Immunohistochemistry shows collagen IV intensity and quantitative analysis of positive cells. (E) Western blot analysis shows renal fibronectin, β-catenin, α-SMA, and KIM-1 protein expression. Results are shown as mean ± SEM (n = 7 per group). * p < 0.05 compared with the control group; # p < 0.05 compared with the cisplatin group.

LCs supplementation alleviates renal fibrosis, necrosis, and macrophage infiltration in cisplatin-induced nephrotoxicity rats. (A) Immunohistochemistry shows F4/80⁺ macrophage infiltration and quantitative analysis. (B) Immunohistochemistry shows cleaved caspase-3-positive cells and quantitative analysis of tubular necrosis. (C) Hydroxyproline levels. (D) Immunohistochemistry shows collagen IV intensity and quantitative analysis of positive cells. (E) Western blot analysis shows renal fibronectin, β-catenin, α-SMA, and KIM-1 protein expression. Results are shown as mean ± SEM (n = 7 per group). * p < 0.05 compared with the control group; # p < 0.05 compared with the cisplatin group.