Figure 2.

HIV cure strategies and their implications within the CNS. (A) Block and Lock involves the use of small molecule drugs to inhibit the transcription of the HIV genome, therefore stopping the formation of any new viral particles. (B) Shock and Kill utilizes latency reversal agents to activate HIV replication in latent cells, therefore making them targets for clearance by the immune system. (C) The utilization of CRISPR can deliver target RNA to the genome of infected cells harboring proviruses and eliminate these proviruses. Created with BioRender.com.