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Complementation of the S. cerevisiae MAPK hog1Δ mutant by Drosophila members of the MAPK superfamily. The D-p38b+ clone clearly complements the high-osmolarity (0.9 M sorbitol)-sensitive growth phenotype of the hog1Δ mutant, while the DJNK+ clone does so only weakly. The Rl+ clone fails to complement this phenotype. When the TGY sequence of D-p38b, a putative MAPKK phosphorylation site, was mutated (T183A and Y185F), complementation was abolished.
