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. 2021 Aug 3;9(8):850. doi: 10.3390/vaccines9080850

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The scPR8-RBD-M2 induces neutralizing antibodies against SARS-CoV-2. (A) Schematic presentation of a spike pseudotyped virus (spike-PV) neutralization assay. SARS-CoV-2 spike protein sequences derived from Wuhan-HU-1, Alpha, Beta and Gamma variant were used for the generation spike-PV. (B) Percentage of neutralization activity of mice sera against Wuhan-PV. (C) Comparison between titers of neutralizing antibodies against spike-PV-Wuhan and spike-PV-variants (Alpha, Beta and Gamma) at 21 days post boost. Y-axis values show reciprocal dilution of the fifty-percent inhibitory concentration (IC₅₀).