Table 2.

Case series (CS); Randomized Clinical Trials (RCT); Retrospective Studies (RS); Clinical Trials (non-randomized, non-controlled) (CT); Controlled Clinical Trials (CCT); and Case Reports (CR). Level of Evidence: I, randomized controlled trial; II, Prospective cohort study patients, compared with a control group of patients treated at the same time and institution; III, Case control study and retrospective cohort study; and IV, case series (no control group or historical control group).

Author	Study Type	n Dogs	n Cats	Level of Evidence
Duprè et al., 2009 [3]	CCT	42		II
Case et al., 2011 [9]	RCT	18		I
Kim et al., 2011 [10]	CS		17	IV
Silva M.A. et al., 2011 [11]	RS	20		II
Manassero M. et al., 2012 [12]	CS	40		IV
Runge et al., 2012 [13]	CS	6		IV
Runge et al., 2013 [14]	RS	18		IV
Case J.B and Ellison G., 2013 [15]	CS	7	1	IV
Adamovich-Rippe et al., 2013 [16]	RS	12		IV
Coisman J.G et al., 2014 [17]	RCT		24	I
Naiman et al., 2014 [18]	RS	5	2	IV
Runge et al., 2014 [19]	RS	22	3	IV
Case et al., 2015 [20]	RCT		18	I
Gonzalez-Gasch and Monnet, 2015 [21]	RS	98		III
Rubin et al., 2015 [22]	CR	1		IV
Silva et al., 2015 [23]	CS	40		IV
Tapia-Araya et al., 2015 [24]	RCT	20		I
Wallace et al., 2015 [25]	CS	7		IV
Hoddinott et al., 2015 [26]	CR	1		IV
Becher-Deichsel et al., 2016 [27]	RS	10		IV
Gandini et al., 2016 [28]	CS	6		IV
Stiles et al., 2016 [29]	RS	14		IV
Wright et al., 2016 [30]	RS	18		IV
Baron et al., 2017 [31]	RS		42	III
Barry et al., 2017 [32]	CCT	16		II
Corriveau et al., 2017 [33]	RS	278		IV
Binder et al., 2018 [34]	RS	132		IV
Coutinho et al., 2018 [35]	RCT	24		I
Mayhew et al., 2018 [36]	RS	22		IV
Sakals et al., 2018 [37]	RCT		30	I
Bydzovsky et al., 2019 [38]	CT	42		IV
Morris et al., 2019 [39]	RS	14		IV
Otomo et al., 2019 [40]	RS	28		IV
Shamir et al., 2019 [41]	RS	27		III
Percival et al., 2020 [42]	RS	13		III
Total		1001	137