Figure 3.

Inhibitory effects of furo[2,3-b]quinoline derivatives on MERS-CoV frameshifting. (A) Chemical structure of furo[2,3-b]quinoline derivatives. (B) The inhibition rate of frameshifting among a total of 88 derivatives, including compound KCB261770 indicated in red, were determined. (C) Inhibition rate of frameshifting was compared between the initial library (blue dots) and furo[2,3-b]quinoline derivatives (red rectangles). The thick bars in the center represent the median values. **** p < 0.0001 (unpaired t-test with Welch’s correction).