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APOBEC mutations are concordant between tumor and viral genomes. APOBEC (A) mutations in tumor genomes, (B) mutations in the viral genome. (C) correlation between host and viral genomes, (D) RNA editing and (E) 3A gene expression, demonstrating linkage between APOBEC activity in virus and host. (F) APOBEC-enriched subjects also had higher IFN-γ scores, suggesting immune upregulation, possibly in response to viral infection.
