Table 2.

Patients tested negative for SARS-CoV-2 vs. patients tested positive (Alpha mutation pattern: N501Y, Del69/70: negative for E484K; Alpha mutation pattern with escape mutation: N501Y, Del69/70: positive for E484K; Beta mutation pattern: N501Y, E484K, and K417N; negative for Del69/70).

Variable	Negative SARS-CoV-2 NAATs (n = 3449)	Positive SARS-CoV-2 NAATs (n = 95)	p-Value
Age (median)	5.0 years	9.3 years	p < 0.0001
	(min 0.0 years; max 17.0 years)	(min 0.0 years; max 17.8 years)
0 ≤ 3 years	37.2% (n = 1284)	21.1% (n = 20)	p = 0.0011
3 ≤ 6 years	19.2% (n = 663)	10.5% (n = 10)	p = 0.0333
6 ≤ 12 years	20.4% (n = 705)	31.6% (n = 30)	p = 0.0014
12 ≤ 18 years	23.1% (n = 797)	36.8% (n = 35)	p = 0.0030
Gender (male)	53.6% (n = 1848)	51.6% (n = 46)	p = 0.3486
SARS-CoV-2-Positive NAATs	-	100.0% (n = 95)	-
Suffering from a	42.6% (n = 1470)	10.5% (n = 10)	p < 0.0001
Chronic Disease
Contact to Somebody Recently Tested Positive for SARS-CoV-2	4.6% (n = 160)	41.1% (n = 39)	p < 0.0001
Symptomatic	18.8% (n = 650)	55.8% (n = 53)	p < 0.0001
Fever	0.0% (n = 0)	28.4% (n = 27)	p < 0.0001
Cough	5.9% (n = 203)	27.4% (n = 26)	p < 0.0001
Rhinitis	6.1% (n = 210)	25.3% (n = 24)	p < 0.0001
Headache	2.9% (n = 100)	9.5% (n = 9)	p = 0.0023
Dyspnea	1.3% (n = 46)	4.2% (n = 4)	p = 0.0436
Sore Throat	2.6% (n = 88)	4.2% (n = 4)	p = 0.3115
Gastrointestinal Symptoms	4.1% (n = 142)	8.4% (n = 8)	p = 0.0617
Myalgia	0.2% (n = 7)	3.2% (n = 3)	p = 0.0020
Dysgeusia and Dysosmia	0.2% (n = 6)	7.4% (n = 7)	p < 0.0001
Admission to Hospital	27.7% (n = 955)	22.1% (n = 21)	p = 0.2464
Ct Value (median)	-	26.0 (min 17.0; max 41.0)	-
Variant Analysis	-	68.4% (n = 65)	-
Wild Type	-	4.2% (n = 4)	-
Alpha Mutation Pattern	-	90.8% (n = 59)	-
Alpha Mutation Pattern with Escape Mutation	-	1.5% (n = 1)
Beta Mutation Pattern		1.5% (n = 1)	-