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Entry of PVs was assessed by titration into various cell lines. (a) Entry of SARS-CoV-1 was highest in HEK293T/17 cells, whilst entry of SARS-CoV-2 and HCoV-NL63 was comparable in both HEK293T/17 and HUH7 cells. (b) MERS-CoV and HCoV-229E preferentially entered HUH7 cells compared to HEK293T/17 cells. Significant differences in titre shown by asterisks: * represents p ≤ 0.05, ** p ≤ 0.005 and *** p ≤ 0.0005, respectively.
