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Role of central nervous system cell types in HIV-mediated accumulation of amyloids: both HIV and HIV-infected cells cross the blood–brain barrier and infect glial cells in the central nervous system. Activated neurons, microglia, astrocytes, pericytes, and endothelial cells play a key role in the accumulation of amyloids. Prolonged accumulation of amyloids, in turn, promotes neurodegeneration.
