Figure 3.

Cell-centric mechanisms underlying virus infection variability. Cells in a given population may be variable at the single-cell level due to at least four principle features: one is heritable genetic variability in the DNA sequence; two is dynamic genetic changes driven by mobile genetic elements or epigenetic differences; three is cell state differences, such as metabolism, infection history, or cell cycle; four is differences in phenotypes, such as macromolecules, organellar positioning with respect to each other (entropy), or the infection state. Figure was prepared by using BioRender.