Figure 3.

Schematic representation of the domains in HIV-1 Pr55^Gag precursor. The myristoyl moiety is indicated at the N-terminus of the precursor. The MA domain drives the interaction between the Pr55^Gag and the PM through a bipartite signal consisting of a HBR domain and the covalently attached myristic acid moiety. The CA domain of Pr55^Gag mediates Pr55^Gag oligomerization and ensures formation of the core of the mature viral particles, and the NC domain, which contains two zinc-finger motifs, corresponds to the primary binding motif to nucleic acids, and contributes to the Pr55^Gag multimerization. The p6 domain contributes to the specificity of Pr55^Gag–gRNA interactions and is essential for viral budding. Pr55^Gag contains also two spacer peptides which are SP1 and SP2.