Figure 3.

SARS-CoV-2 labeling in the lung of the affected cat. (A) In situ hybridization (ISH) (left panels) showing labeling (pink/reddish labeling) for SARS-CoV-2 RNA in bronchial and bronchiolar epithelial cells and bronchial glands. Immunohistochemistry (IHC) (right panels) showing staining for the SARS-CoV-2 N protein (brown stain) in bronchial and bronchiolar epithelial cells and bronchial glands. Tissue section were counter stained with hematoxylin. (B) ISH and IHC performed in the same section demonstrating co-localization of viral RNA labeling (pink/reddish) and viral protein (N), indicating active SARS-CoV-2 replication in the lung of the cat.