Figure 2.

Crystal structure of Pf4r*. (a) The structure is coloured from the N-terminus (blue) to the C-terminus (red) in ribbon representation showing the symmetrical dimer formed by two chain As. The helices are numbered H1–H6, and the surface is rendered in transparent grey. (b) The Pf4r* Type A homodimer structure (brown) overlaid with the distantly related E. coli P2 repressor C (cyan) (PDB 2XCJ), showing high conservation in structure. (c) Overlay of the two types of Pf4r* symmetric homodimer (Type A in brown, Type B in green) observed in the solved crystal. Differences arise within the spacing of the predicted DNA-binding helices.