Table 2.
Histopathologic lesions in pericardia affected by IP, evaluated on H&E sections, except fibrosis which was scored in Masson’s trichrome-stained sections.
| Histopathologic Lesions | Score | - | |||
|---|---|---|---|---|---|
| Total N = 22 | Present N (%) |
Mild/1 N (%) |
Moderate/2 N (%) |
Severe/3 N (%) |
Absent/0 N (%) |
| Mesothelium | |||||
| Loss | 20 (90.9) | 2 (9.9) | 8 (34.8) | 10 (43.2) | 2 (9.8) |
| Reactive | 9 (39) | 2 (9.9) | 6 (26.5) | 1 (5.7) | 13 (55.7) |
| Papillary hyperplasia | 4 (18.2) | 0 | 1 (5.7) | 3 (14) | 18 (76.5) |
| Atypical proliferation | 3 (14) | 0 | 1 (5.7) | 2 (9.9) | 19 (80.7) |
| Superficial/visceral fibrin exudation | 7 (30.7) | 5 (22.5) | 1 (5.7) | 1 (5.7) | 15 (64) |
| Edema | 4 (18.2) | 2 (9.9) | 2 (9.9) | 0 | 18 (76.5) |
| Hemorrhage | 14 (58.5) | 6 (26.5) | 4 (18.2) | 4 (18.2) | 8 (39.4) |
| Granulation tissue | 14 (58.5) | 7 (30.7) | 4 (18.2) | 3 (14) | 8 (39.4) |
| Fibrosis (Masson’s trichrome) | 19 (80.7) | 2 (9.9) | 11 (50) | 6 (26.5) | 3 (14) |
| Neutrophils, infiltrate | |||||
| Intravascular/marginating | 14 (58.5) | 10 (43.2) | 3 (14) | 1 (5.7) | 8 (39.4) |
| Perivascular Total |
16 (78.3) | 12 (51.5) | 0 | 4 (18.2) | 6 (26.5) |
| 17 (72.4) | 13 (55.7) | 0 | 4 (18.2) | 5 (22.4) | |
| Lymphocytes and plasma cells, infiltrate | |||||
| Visceral/superficial zone Fibrous/deep zone Total |
17 (72.4) | 11 (47.4) | 5 (22.4) | 1 (5.7) | 5 (22.4) |
| 19 (80.7) | 12 (51.5) | 2 (9.9) | 5 (22.4) | 3 (14) | |
| 20 (84.9) | 9 (39) | 9 (39) | 2 (9.9) | 2 (9.9) | |
| Macrophages, infiltrate | |||||
| Visceral/superficial zone Fibrous/deep zone Total |
16 (68.2) | 12 (51.5) | 4 (18.2) | 0 | 6 (26.5) |
| 20 (84.9) | 12 (51.5) | 7 (30.7) | 1 (5.7) | 2 (9.9) | |
| 20 (84.9) | 11 (47.4) | 9 (39) | 0 | 2 (9.9) | |
| Overall inflammation severity § | 22 (100) | 12 (51.5) | 5 (22.4) | 5 (22.4) | 0 |
§ Overall inflammation severity included a score comprehensive of all inflammatory findings (fibrin exudation, edema, hemorrhage, granulation tissue, presence of infiltrates of inflammatory cells).