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. 2021 Aug 5;13(8):1550. doi: 10.3390/v13081550

Figure 4.

Figure 4

fACE2 RNA and SARS-CoV-2 viral RNA quantification in feline tissues. Extraction of SARS-CoV-2 and ACE2 RNA was performed as described from tissues samples collected at either 4 or 8 dpi. Tissue samples included nasal turbinates, tracheobronchial lymph node (TBLN), trachea, kidney, and lung. (A) SARS-CoV-2 RNA copies were detected in all tissues collected from cats inoculated with SARS-CoV-2. No viral RNA was detected in tissues from sham-inoculated cats. In SARS-CoV-2-infected cats, viral RNA copies were slightly increased in the TBLN between 4 to 8 dpi (p = 0.0567), while viral RNA load in the lungs significantly decreased over the same period (p = 0.0007). (B) fACE2 receptor RNA is significantly increased in the kidney of SARS-CoV-2-infected cats at 4 dpi compared to sham-inoculated controls (p < 0.0001) SARS-CoV-2-infected cats at 8 dpi (p < 0.0001). Data are expressed as means ± SEM. n = 6 cats per group. Statistical comparisons made via two-way ANOVA. *** p < 0.001; **** p < 0.0001.