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. Author manuscript; available in PMC: 2022 Jul 8.
Published in final edited form as: Cell. 2021 Jun 10;184(14):3612–3625.e17. doi: 10.1016/j.cell.2021.05.008

Figure 7. Proposed model for MLO formation by DMA-tudor modules.

Figure 7.

Working model of DMA modifications bound by tudor domains and how these DMA-tudor modules control the composition of MLOs. Unmodified arginine does not support assembly, while aDMA (red), and sDMA (blue) allow for assembly with tudor domain proteins (cyan and orange) in trans. If a protein bears both modifications, the two distinct bodies may “dock” with one another.