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. 2021 Aug 24;15:3697–3708. doi: 10.2147/DDDT.S321879

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© 2021 Wang et al.

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PR regulates UUO-induced TGF-β1/smads signaling pathway transduction. (A–E) According to the results of Wb, PR significantly inhibited the activation of the fibrotic pathway TGF-β1/smad3 in the kidney of UUO mice, while smad7 was upregulated. ^##P<0.01, ^###P<0.001, vs Sham group; *P<0.05, **P<0.01, vs UUO group; ^†P<0.05, ^††P<0.01, vs UUO + PRL group.