Table 1.

Neurological Events Noted with Approved CAR T-Cell Products for Large B-Cell Lymphoma

Axicabtagene Ciloleucel	Lisocabtagene Maraleucel	Tisagenlecleucel
Encephalopathy: Includes encephalopathy, cognitive disorder, confusional state, depressed level of consciousness, disturbed attention, hypersomnia, leukoencephalopathy, memory impairment, mental status changes, paranoia, somnolence, and stupor	Encephalopathy: Includes encephalopathy, confusional state, encephalopathy, mental status changes, somnolence, lethargy, amnesia, cognitive disorder, depressed level of consciousness, memory impairment, flat affect, depersonalization, disturbance in attention, incoherent, and hypersomnia	Encephalopathy: Includes encephalopathy, cognitive disorder, confusional state, depressed level of consciousness, disturbance in attention, lethargy, mental status changes, somnolence, and automatism
Delirium: Includes agitation, delirium, disorientation, hallucination, hyperactivity, irritability, restlessness, and delusion	Delirium: Includes delirium, agitation, disorientation, delusion, hallucination, visual hallucination, and irritability	Delirium: Includes delirium, agitation, hallucination, hallucination visual, irritability, and restlessness
Headache	Headache: Includes headache and migraine	Headache: Includes headache and migraine
Dizziness: Includes dizziness, presyncope, syncope	Dizziness: Includes dizziness and syncope	Sleep disorder: Includes sleep disorder, nightmares, and insomnia
Aphasia: Includes aphasia, dysphasia	Aphasia: Includes aphasia, dysarthria, dysphemia, dysphonia, slow speech, and speech disorder	Anxiety
Tremor	Tremor: Includes tremor and essential tremor
Ataxia	Ataxia: Includes ataxia and gait disturbance
Motor dysfunction: Includes muscle spasms, muscular weakness	Cerebellar: Includes cerebellar syndrome, dysmetria, balance disorder, dyskinesia and impaired hand-eye coordination
Seizure
Dyscalculia
Myoclonus

Note: Data from references.^3–6