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. 2021 Aug 24;17:2791–2802. doi: 10.2147/NDT.S292471

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© 2021 Guo et al.

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MiR-101 protected ischemic brain injury through targeting JAK2. (A–D) The neuronal cells were transfected with miR-101 mimics or miR-101 inhibitor, or co-transfected with miR-101 mimics and sh-JAK2, or miR-101 inhibitor and sh-JAK2, then cells were exposed to OGD/R or not. (A and B) The protein levels of JAK2 (A) and p-STAT3 (B) were evaluated by Western blot (n = 3). (C) The cell viability was evaluated by MTT assay (n = 3). (D) The apoptosis was detected by flow cytometry (n = 3). (E) Rats were subjected to cortical injection of miR-101 mimics, miR-101 inhibitor, or cortical co-injection with miR-101 mimics and sh-JAK2, or miR-101 inhibitor and sh-JAK2, and were then exposed to MCAO/R. Infarct volume in rats with cerebral I/R injury (n = 6). Data were presented as mean ± SD. *p < 0.05, **p <0.01.