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. 2021 Apr 9;12(9):680–694. doi: 10.1007/s13238-021-00839-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Death domain signaling in Fas and CBM signalosome pathways. (A) Domain architecture of DISC components including receptor Fas, adaptor FADD, and effector caspase-8. (B) Crystal structure of the Fas DD-FADD DD complex (PDB ID: 3OQ9) displays helical assembly similar to the MyD88-IRAK4-IRAK2 DD complex described above. (C) Cryo-EM structure of caspase-8 tDEDs (PDB ID: 5L08) shows helical assembly into filaments. (D) Extensive inter-subunit interactions in caspase-8 tDED filaments. (E) Domain architecture of CBM signalosome components and a nucleated polymerization model of CARMA1 CARD-BCL10 CARD filaments