Table 2.
Predictive Accuracies of the DETECT Algorithm and 2015 ESC/ERS Guidelines
| 2018 Revised Hemodynamic PAH Definition and All DLCO Values (N=68) | 2018 Revised Hemodynamic PAH Definition and DLCO ≥ 60% predicted (N=27) | |||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | |
|
DETECT
(95% CI) |
1.00 (0.69-1.00) |
0.29 (0.18-0.43) |
0.20 (0.10-0.33 |
1.00 (0.80-1.00) |
1.00 (0.29-1.00) |
0.29 (0.13-0.51) |
0.15 (0.03-0.38) |
1.00 (0.59-1.00) |
|
2015 ESC/ERS Guidelines
(95% CI) |
0.80 (0.44-0.97) |
0.57 (0.43-0.70) |
0.24 (0.11-0.42) |
0.94 (0.81-0.99) |
0.67 (0.09-0.99) |
0.67 (0.45-0.84) |
0.2 (0.03-0.56) |
0.94 (0.71-1.00) |
PAH=Pulmonary arterial hypertension; DLCO= Diffusing capacity for carbon monoxide; PPV=Positive predicted value; NPV=Negative predictive value; ESC/ERS=European Society of Cardiology/European Respiratory Society; 95% CI= 95% confidence interval.