Table 3.
Predictive Accuracies of the DETECT Algorithm and 2015 ESC/ERS Guidelines
| 2009 PAH Hemodynamic Definition From Original DETECT Study and All DLCO Values (N=70) | 2009 PAH Hemodynamic Definition From Original DETECT Study and DLCO ≥ 60% predicted (N=28) | |||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | |
|
DETECT
(95% CI) |
1.00 (0.82-1.00) |
0.33 (0.21-0.48) |
0.36 (0.23-0.50) |
1.00 (0.80- 1.00) |
1.00 (0.48-1.00) |
0.30 (0.13-0.53) |
0.24 (0.08-0.47) |
1.00 (0.59-1.00) |
|
2015 ESC/ERS Guidelines
(95% CI) |
0.74 (0.49-0.91) |
0.61 (0.46-0.74) |
0.41 (0.25-0.59) |
0.86 (0.71-0.95) |
0.60 (0.15-0.95) |
0.70 (0.47-0.87) |
0.30 (0.07-0.65) |
0.89 (0.65-0.99) |
PAH=Pulmonary arterial hypertension; DLCO= Diffusing capacity for carbon monoxide; PPV=Positive predicted value; NPV=Negative predictive value; ESC/ERS=European Society of Cardiology/European Respiratory Society; 95% CI= 95% confidence interval.