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. 2020 May 11;109(3):257–276. doi: 10.1007/s00223-020-00702-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Synovial joint development in the mouse. Longitudinal views depicting key steps in the formation of the knee joint. a The first sign of a presumptive joint is a condensation of Col2 + limb bud progenitors at the presumptive joint site; b Joint specification is marked by induction of Gdf5 in the interzone and downregulation of Col2a1; c A joint space is formed by cavitation after progenitors for a variety of secondary joint structures are specified from the Gdf5 + progenitor pool; d Maturation of the synovial joint of the knee occurs during development and early postnatal life.

Reproduced from Salazar et al. [165], with permission