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. 2020 May 11;109(3):257–276. doi: 10.1007/s00223-020-00702-6

Fig. 6.

Fig. 6

Effect size and risk allele frequency of published osteoarthritis genetic risk loci. Each circle represents a published osteoarthritis risk single-nucleotide variant plotted with its odds ratio (OR; y axis) as a function of the risk allele frequency (x-axis). The different size and colour of each circle shows the sibling relative risk ratio (λs) and the percentage of variance explained on the liability scale respectively (h2L; calculated assuming 13.5% prevalence of OA). Gene annotations are

taken from the Ensembl genome browser (human assembly GRCh37). The majority are common variants with small (OR < 2.0) effect sizes, only those with OR > 2.0 are named here