Skip to main content
. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Brain Res. 2021 Jul 20;1768:147587. doi: 10.1016/j.brainres.2021.147587

Figure 2. Prenatal exposure to alcohol results in increased dendritic length and complexity in hippocampal CA2/3 neurons of postnatal day 10 (PND) offspring.

Figure 2.

(A) Representative Z-stack confocal images illustrate dendritic branches of CA2/3 pyramidal neurons from PND 10 offspring following prenatal alcohol exposure (Alcohol) and their pair-fed controls (PF-Cont). (B) A 3-dimentional Sholl analysis revealed significantly more intersections of the dendritic processes at 50-140 μm from the center of soma of CA2/3 field neurons in the Alcohol rat, compared to the PF-Cont group. (C) CA2/3 neurons from Alcohol rats exhibited increased number of the primary dendrites compared to PF-Cont. (D) The total dendrite length, and (E) the number of branches were significantly increased in the CA2/3 field of Alcohol compared to PF-Cont. Significance was established a priori at P<0.05; * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001. All data are presented as mean ± SEM. n=6 animals derived from 6 litters; 4 neurons/animal.