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. 2021 May 30;12(9):695–716. doi: 10.1007/s13238-021-00852-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

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Construction of single-nucleus transcriptomic atlas of the monkey hippocampus. (A) Flow chart of snRNA-seq and bioinformatics analysis of the monkey hippocampus. Young, n = 7; old, n = 8 monkeys. (B) Left, UMAP plot showing distribution of different cell types in the monkey hippocampus. Right, UMAP plots showing distribution of different cell types in the young (top) and old (bottom) hippocampus. (C) UMAP plots showing the expression profiles of indicated cell-type-specific marker genes of corresponding cell types in the monkey hippocampus. (D) Heatmap showing the expression profiles of top 30 cell-type-specific marker genes of different cell types in the monkey hippocampus with their enriched functional annotations on the right. (E) Network plot showing transcriptional regulators of cell-type-specific marker genes (adjusted P-value < 0.05, |logFC| > 1) of different cell types in the monkey hippocampus