Table 2.
CircRNAs as Potential Diagnostic Biomarkers in Lung Cancer
| circRNA | Function | Mechanism | Expression Pattern | Cell Characteristics | Clinical Characteristics | References |
|---|---|---|---|---|---|---|
| circ-ITCH | miRNA sponge | circ-ITCH↓- miR-7↑/ miR-214↑-Wnt/β-catenin↑ | Down | Proliferation↓ | Age (≥60), TNM | [37] |
| circPVT1 | miRNA sponge | circPVT1↑-miR-125b↓-E2F2 pathway↑ | Up | Proliferation↑, migration↑, invasion↑, apoptosis↓ | Distant metastasis | [38] |
| circMET | miRNA sponge | circMET↑-miR-145-5p↓-CXCL3↑ | Up | Proliferation↑, migration↑, invasion↑ | TNM, LNM, tumor differentiation, OS | [39] |
| circGFRA1 | miRNA sponge | circGFRA1↑-miR-188-3p↓-PI3K/AKT↑ | Up | Proliferation↑ | Unknown | [40] |
| hsa_circ_0013958 | miRNA sponge | hsa_circ_0013958↑-miR-134↓-cyclin D1↑ | Up | Proliferation↑, migration↑, invasion↑, apoptosis↓ | TNM, LNM | [41] |
| circ_0005280 | Unknown | Unknown - | Down | Unknown | Age (≥60), tumor size | [62] |
| circRNA100146 | miRNA sponge | circRNA100146↑- miR-361-3p ↓/miR-615-5p↓-SF3B3↑ | Up | Proliferation↑, migration↑, invasion↑, apoptosis↓ | Unknown | [66] |
| hsa_circ_0001946 | miRNA sponge | hsa_circ_0001946↓-NER signaling pathway↑ | Down | Proliferation↓, migration↓, invasion↓, apoptosis↑, cisplatin sensitivity↑ | Unknown | [70] |
| hsa_circ_0030998 | miRNA sponge | hsa_circ_0030998↓-miR-558↑-MMP1/MMP17↓ | Down | Proliferation↓, migration↓, invasion↓, Taxol resistance↓ | TNM, distal metastasis | [72] |
| circFARSA | miRNA sponge | circFARSA↑-miR-330-5p↓/miR-326↓-FASN↑ | Up | Migration↑, invasion↑ | Gender | [73] |
| circ-CCS | miRNA sponge | circ-CCS↑-miR-383↓-E2F7↑ | Up | Proliferation↑, migration↑, apoptosis↓ | TNM, LNM, tumor size | [77] |
| circ-IGF1R | miRNA sponge | circ-IGF1R↓–miR-1270↑–VANGL2↓ | Down | Migration↓, invasion↓ | LNM, tumor size | [82] |
| circRNA_102179 | miRNA sponge | circRNA_102179↑-miR-330-5p↓-HMGB3↑ | Up | Proliferation↑, migration↑, invasion↑ | Unknown | [95] |
| circSATB2 | miRNA sponge | circSATB2↑-miR-326↓-FSCN1↑ | Up | Proliferation↑, migration↑, invasion↑ | LNM | [96] |
| circ-ZKSCAN1 | miRNA sponge | circ-ZKSCAN1↑-miR-330-5p↓-FAM83A↑ | Up | Proliferation↑, migration↑ | OS, tumor size, clinical stage | [97] |
| hsa_circ_0007059 | miRNA sponge | hsa_circ_0007059↓-miR-378↑-Wnt/β-catenin↑/ERK1/2↑ | Down | Proliferation↓, EMT↓, apoptosis↑ | TNM, LNM | [99] |
| circ-PITX1 | miRNA sponge | circ-PITX1↑-miR-1248↓-CCND2↑ | Up | Proliferation↑, migration↑, invasion↑, glycolysis↑, glutamine metabolism↑, apoptosis↓ | Unknown | [126] |
| circ_0000429 | miRNA sponge | circ_0000429↑-miR-1197↓-MADD↑ | Up | Proliferation↑, migration↑, invasion↑, apoptosis↓ | Unknown | [132] |
| circ_0001287 | miRNA sponge | circ_0001287↓-miR-21↑-PTEN↓ | Down | Proliferation↓, migration↓, invasion↓, radio-resistance↓ | N status, histological grade | [136] |
| hsa_circ_0000064 | Unknown | hsa_circ_0000064↑-caspase-3/9↑/ bax↑/p21↑/CDK6↑/cyclin D1↑/bcl-2↓/MMP-2/9↑ | Up | Proliferation↑, migration↑, invasion↑, apoptosis↓ | TNM, LNM, T stage | [147] |
Notes: ↑, up-regulated; ↓, down-regulated.
Abbreviations:TNM, the high stage of tumor node metastasis; LNM, lymph node metastasis; OS, overall survival.