Table 3.

CircRNAs as Potential Prognostic Biomarkers in Lung Cancer

circRNA	Function	Mechanism	Expression Pattern	Cell Characteristics	Clinical Characteristics	References
circFGFR3	miRNA sponge	circFGFR3↑-miR‐22‐3p↓-Gal‐1↑/p‐AKT↑/p‐ERK1/2↑	Up	Proliferation↑, invasion↑	TNM, LNM, tumor size, tumor differentiation, OS	[43]
circ_0003645	miRNA sponge	circ_0003645↑-miR-1179↓-TMEM14A↑	Up	Proliferation↑, migration↑, invasion↑, apoptosis↓	TNM, LNM, OS	[46]
CDR1as	miRNA sponge	CDR1as↑-miR-7↓-EGFR↑/CCNE1↑/PIK3CD↑	Up	Proliferation↑, apoptosis↓	TNM, LNM, OS, tumor size	[47,59]
circ_POLA2	miRNA sponge	circ_POLA2↑-miR-326↓-GNB1↑	Up	Unknown	Distant metastasis, TNM, OS	[48]
circ-FOXM1	miRNA sponge	circ-FOXM1↑-miR-1304-5p↓-PPDPF↑/MACC1↑	Up	Proliferation↑, migration↑, invasion↑, apoptosis↓	TNM, LNM	[49]
circPIP5K1A	miRNA sponge	circPIP5K1A↑-miR‐600↓-HIF‐1α↑ circPIP5K1A↑-miR‑101↓-ABCC1↑	Up	Proliferation↑, migration↑, invasion↑, apoptosis↓, EMT↑, cisplatin sensitivity↓	Unknown	[86,87]
circRNA_010763	miRNA sponge	circRNA_010763↑-miR-715↓-c-Myc↑	Up	Proliferation↑, migration↑, invasion↑	Unknown	[93]
circRNA_100876	Unknown	Unknown	Up	Unknown	LNM, tumor staging, OS	[101]
circ-ANXA7	miRNA sponge	circ-ANXA7↑- miR-331↓-LAD1↑	Up	Proliferation↑, migration↑, invasion↑	TNM, LNM, tumor size, recurrence status, OS	[119]
circ‑PTEN	miRNA sponge	circ‑PTEN↓-miR-155↑/miR-330-3p↑-PTEN↓	Down	Proliferation↓	TNM, tumor size, OS	[140]
hsa_circ_0008003	miRNA sponge	hsa_circ_0008003↑-miR-488↓-ZNF281↑	Up	Proliferation↑, migration↑, invasion↑	TNM, LNM	[142]
circ-MTHFD2	Unknown	Unknown	Up	Unknown	TNM, LNM, tumor size, recurrence, smoking history, OS	[157]

Notes: ↑, up-regulated; ↓, down-regulated.

Abbreviations: TNM, the high stage of tumor node metastasis; LNM, lymph node metastasis; OS, overall survival.