Figure 3.

Figure shows the moderating effect of depressive traits (A) and nicotine dependence severity (B) on changes in response bias following nicotine relative to a placebo. For visualization purposes, predicted response bias for individuals with depressive trait scores and nicotine dependence scores at the mean (“Mean”), 1 SD above the mean (“High”) and 1 SD below the mean (“Low”) are plotted. The reward-enhancing effects of nicotine were stronger in young light smokers scoring higher on depressive personality traits and also in those reporting a greater sense of being “hooked” on nicotine.