. 2021 Jun 19;10(13):e020597. doi: 10.1161/JAHA.120.020597

Table 2.

Comparative Effects of Adenosine and Dobutamine Infusion on Systemic and Coronary Hemodynamic Parameters in the Study Population (n=60)

	BL1	ADO	BL2	DOB 10	DOB 20	DOB 30	DOB 40/50/ATR	DOBmax
HR, bpm	73±12	90±13^*	73±12	83±13^*	103±16^* ^, ^†	124±15^* ^, ^†	140±8^* ^, ^†	139±8^* ^, ^‡
Systolic‐BP, mm Hg	126±11	115±14^*	126±11	127±12	130±14^* ^, ^†	133±15^* ^, ^†	140±15^* ^, ^†	136±16^* ^, ^‡
Diastolic‐BP, mm Hg	69±7	69±8	69±7	69±7	70±8	70±8	70±8	70±8
RPP×10³, bpm∙mm Hg	9.2±1.7	10.3±1.9^*	9.2±1.7	10.5±1.8^*	13.4±2.6^* ^, ^†	16.4±3.4^* ^, ^†	19.6±2.4^* ^, ^†	18.9±2.7^* ^, ^‡
Pa, mm Hg	88±7	84±8^*	88±7	89±7	90±7^* ^, ^†	91±8^* ^, ^†	92±8^*	92±8^* ^, ^‡
Pd, mm Hg	81±7	70±8^*	81±7	79±7^*	77±8^* ^, ^†	77±8*	77±8^*	77±8^* ^, ^‡
Overall‐ΔP, mm Hg	7±3	14±4^*	7±3	10±3^*	13±4^* ^, ^†	14±5^* ^, ^†	15±4^* ^, ^†	15±5^*
Conventional‐FFR	0.92±0.03	0.84±0.04^*	0.92±0.03	0.89±0.03^*	0.87±0.05^* ^, ^†	0.85±0.06^* ^, ^†	0.84±0.04^* ^, ^†	0.84±0.06^*
s‐Pa, mm Hg	103±10	93±11^*	103±10	103±10	104±10	105±10^*	107±9^*	106±11^* ^, ^‡
s‐Pd, mm Hg	96±10	83±11^*	96±10	96±10	97±11	98±12^*	99±11^*	99±11^* ^, ^‡
Systolic‐ΔP, mm Hg	7±3	10±5^*	7±3	7±4	7±7	7±7	8±5	7±7^‡
d‐Pa, mm Hg	84±11	72±12^*	84±11	83±12	79±14^* ^, ^†	76±13^* ^, ^†	75±13^* ^, ^†	75±13^*
d‐Pd, mm Hg	75±11	57±12^*	75±11	71±12^*	64±15^* ^, ^†	59±14^* ^, ^†	58±13^* ^, ^†	57±13^*
Diastolic‐ΔP, mm Hg	9±3	15±6^*	9±3	12±4^*	15±6^* ^, ^†	17±6^* ^, ^†	17±4^*	18±6^* ^, ^‡
Diastolic‐FFR	0.89±0.04	0.79±0.08^*	0.89±0.04	0.86±0.05^*	0.81±0.08^* ^, ^†	0.78±0.08^* ^, ^†	0.77±0.05^* ^, ^†	0.76±0.08^* ^, ^‡

Data are expressed as mean±SD. ADO indicates adenosine (140 µg/kg/min); BL1, basal conditions before adenosine infusion; BL2, basal conditions before dobutamine infusion; BP, blood pressure; bpm, beats per minute; diastolic‐ΔP, mean pressure gradient across the MB during diastole; DOB 10, 10 µg/kg/min of DOB; d‐Pa, mean aortic blood pressure obtained during diastole; d‐Pd, mean distal intracoronary pressure obtained during diastole; DOB, dobutamine; DOB 20, 20 µg/kg/min of DOB; DOB 30, 30 µg/kg/min of DOB; DOB 40/50/ATR, 40 or 50 µg/kg/min of DOB, or atropine; DOBmax, peak DOB dose; FFR, fractional flow reserve; HR, heart rate; MB, myocardial bridging; overall‐ΔP, mean overall pressure gradient across the MB; Pa, mean aortic blood pressure obtained during the whole cardiac cycle; Pd, mean distal intracoronary pressure obtained during the whole cardiac cycle; RPP, rate–pressure product; s‐Pa, mean aortic blood pressure obtained during systole; s‐Pd, mean distal intracoronary pressure obtained during systole; and systolic‐ΔP, mean pressure gradient across the MB during systole.

P<0.05 vs BL.

^{^†}

P<0.05 vs preceding value.

^{^‡}

P<0.05 vs ADO.